RNA - Senior Brotherhood leaders Essam el-Erian and Mohamed Beltagi were sentenced to death, while Mohammad Badie, the Brotherhood's spiritual leader, was handed a life sentence, Al-Jazeera reported.
Prominent photojournalist Mahmoud Abu Zeid, also known as Shawkan, was handed a five-year sentence but should walk free for time served. He was arrested in August 2013 while covering the killings in Cairo.
Lawyers for Shawkan said he would be out in a "few days".
Those sentenced on Saturday are accused of security-related offences, including incitement to violence and organising illegal protests.
On August 14, 2013, police dispersed a mass sit-in protest in Cairo's Rabaa al-Adawiya Square. The security forces killed more than 800 people in a matter of hours, in what Human Rights Watch (HRW) concluded "likely amounted to crimes against humanity".
Government forces moved in with armoured vehicles, bulldozers, and hundreds of security forces moving in the early hours.
According to HRW, about 85,000 protesters joined the sit-in, which extended for over 45 days and grew larger and more organised with time.
The protest was staged by supporters of Mohamed Morsi, Egypt's first elected president and Muslim Brotherhood leader, who was overthrown by the military a few weeks earlier.
Thousands were arrested on the day of the massacre and in the months following.